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Generic Name: Semaglutide
FDA Approval Year: 2021
BMI Criteria (Obesity): BMI ≥ 30 or BMI ≥ 27 with at least one weight-related condition
Rx Required: Yes
Best in class for weight loss
Helps you end meals earlier
Help keeps you full longer
Weight Loss @1-year = 15%
Nausea is common when starting
Expensive, may be a high co-payment
Not all insurances cover it (usually needs
MD supervision, detailed diet, exercise
and behavior counseling)
Generic Name: Liraglutide
FDA Approval Year: 2014
BMI Criteria (Obesity): BMI ≥ 30 or BMI ≥ 27 with at least one weight-related condition
Rx Required: Yes
Helps you end meals earlier
Helps keep you full longer
Weight Loss @1-year = 6%
Treatment for Type 2 Diabetes
Good side effect profile
Nausea is common when starting
Once a day injection
Expensive, may be a high co-payment
Not all insurances cover it
Usually needs MD supervision, detailed diet, exercise and behavior counseling
Generic Name: Phentermine
FDA Approval Year: 1959
BMI Criteria (Obesity): Typically used for short-term treatment in individuals with a BMI ≥ 30
Rx Required: Yes
Suppresses Appetite
Many Doses Available
Cheap
May develop tolerance and regain weight
Can increase blood pressure & heart rate
Not safe for use in some people (Ask MD)
Generic Name: Phentermine + Topiramate
FDA Approval Year: 2012
BMI Criteria (Obesity): BMI ≥ 30 or BMI ≥ 27 with at least one weight-related condition
Rx Required: Yes
Suppresses Appetite
Combination Therapy
Weight Loss @1-year = 6-9%
Side Effect: Concentration difficulties
Side Effect: Memory loss
Weight Loss @2-year = 7-9%
Generic Name: Bupropion + Naltrexone
FDA Approval Year: 2014
BMI Criteria (Obesity): BMI ≥ 30 or BMI ≥ 27 with at least one weight-related condition
Rx Required: Yes
Suppresses Appetite
Combination Therapy
Weight Loss @1-year = 4%
Must not be on Opiates
Not safe for use in some people (Ask MD)
No Weight Loss Study >1-year = ???
Generic Name: Tirzepatide
FDA Approval Year: 2022
BMI Criteria (Obesity): BMI ≥ 30 or BMI ≥ 27 with at least one weight-related condition
Rx Required: Yes
Proven effective for significant weight loss.
Reduces appetite and food intake.
Administered weekly by injection.
Common side effects include gastrointestinal issues and injection site reactions.
Potential risk of thyroid tumors (based on animal studies).
Weight regain likely upon discontinuation
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